Publications - Neuroscience

Neural Structures and Mechanisms Involved in Scene and Building Recognition: A Review and Interpretation

Submitted to Brain Structure and Function (2009) (request reprints by email)

Abstract:  Since the discovery in 1996 that a region within caudal parahippocampal cortex subserves learning and recall of topographical information, numerous studies aimed at elucidating the structures and pathways involved in navigation and scene and building recognition have been published.  Neuroimaging studies, in particular, have revealed the locations and identities of the principal cortical components that mediate these faculties, and lesion studies have been employed in efforts to relate structure and function in these components.  The present study has a more specific goal: to determine the organization of neural structures specifically involved in scene and building recognition.  This effort is based on a meta-analysis of neuroimaging studies of building and scene processing in human subjects, combined with reviews of the results of lesions on this type of processing, single neuron studies, and available hodological data in non-human primates.  A cortical hierarchy of structures that mediate scene and building recognition is established based on these data, and an attempt is made to determine the function of the individual components of the system.

 

Dual Separate Pathways for Sensory and Hedonic Aspects of Taste

Brain Research Bulletin 62: 271-283 (2004)  PDF

Abstract:  It is proposed that in the gustatory system there exist separate sensory and hedonic (reward-aversion) representations in each of the primary structures in which processing of gustatory stimuli occurs. Anatomical and physiological data are used to determine putative separate sensory and hedonic representations in the nucleus of the solitary tract, parabrachial complex, gustatory thalamus, and cortical gustatory areas. In the nucleus of the solitary tract, the sensory representation is located in the rostralmost part of the nucleus, and the hedonic representation most probably in the intermediate parts. In the parabrachial complex, the sensory representation is located in the central medial and ventral lateral subnuclei, and in the waist area, and the hedonic representation in the inner division of the external lateral subnucleus and in the external medial subnucleus. In the rodent gustatory thalamic relay, the sensory representation occurs in the dorsal lateral parts of the nucleus, and the hedonic representation in the ventromedial parts. In rodent gustatory insular cortex, the sensory representation is found in anterior parts of the gustatory area, and the hedonic representation caudal to the sensory representation. The function of the separate sensory and hedonic representations is discussed in relation to the conditioned taste aversion paradigm.

 

Representations of Motivational Drives in Mesial Cortex, Medial Thalamus, Hypothalamus, and Midbrain

Brain Research Bulletin 61: 25-49 (2003)  PDF

Abstract:  We propose that neural representations of motivational drives, including sexual desire, hunger, thirst, fear, power-dominance, the motivational aspect of pain, the need for sleep, and nurturance, are represented in four areas in the brain. These are located in the medial hypothalamic/preoptic area, the periaqueductal gray matter (PAG) in the midbrain/pons, the midline and intralaminar thalamic nuclei, and in the anterior part of the mesial cortex, including the medial prefrontal and anterior cingulate areas. We attempt to determine the locations of each of these representations within the hypothalamus/preoptic area, periaqueductal gray and cortex, based on the available literature on activation of brain structures by stimuli that evoke these forms of motivation, on the effects of electrical and chemical stimulation and lesions of candidate structures, and on hodological data. We discuss the hierarchical organization of the representations for a given drive, outputs from these representations to premotor structures in the medulla, caudate-putamen, and cortex, and their contributions to involuntary, learned-sequential (operant) and voluntary behaviors.

 

Fear and Power-Dominance Motivation: Proposed Contributions of Peptide Hormones Present in the Cerebrospinal Fluid

Neuroscience and Biobehavioral Reviews 27: 247-267 (2003)  PDF

Abstract:  We propose that fear and power-dominance drive motivation are generated by the presence of elevated plasma and cerebrospinal fluid (CSF) levels of certain peptide hormones. For the fear drive, the controlling hormone is corticotropin releasing factor, and we argue that elevated CSF and plasma levels of this peptide which occur as a result of fear-evoking and other stressful experiences in the recent past are detected and transduced into neuronal activities by neurons in the vicinity of the third ventricle, primarily in the periventricular and arcuate hypothalamic nuclei. For the power-dominance drive, we propose that the primary signal is the CSF concentration of vasopressin, which is detected in two circumventricular organs, the subfornical organ and organum vasculosum of the lamina terminalis. We suggest that the peptide-generated signals detected in periventricular structures are transmitted to four areas in which neuronal activities represent fear and power-dominance: one in the medial hypothalamus, one in the dorsolateral quadrant of the periaqueductal gray matter, a third in the midline thalamic nuclei, and the fourth within medial prefrontal cortex. The probable purpose of this system is to maintain a state of fear or anger and consequent vigilant or aggressive behavior after the initial fear- or anger-inducing stimulus is no longer perceptible. We further propose that all the motivational drives, including thirst, hunger and sexual desire are generated in part by non-steroidal hormonal signals, and that the unstimulated motivational status of an individual is determined by the relative CSF and plasma levels of several peptide hormones.

 

Innate visual object recognition in vertebrates: some proposed pathways and mechanisms.

Comparative Biochemistry and Physiology - Part A: Molecular & Integrative Physiology 132: 861-891 (2002) PDF

Sandia Research Center, 21 Perdiz Canyon Road, Placitas, NM 87043, USA.
Almost all vertebrates are capable of recognizing biologically relevant stimuli at or shortly after birth, and in some phylogenetically ancient species visual object recognition is exclusively innate. Extensive and detailed studies of the anuran visual system have resulted in the determination of the neural structures and pathways involved in innate prey and predator recognition in these species [Behav. Brain Sci. 10 (1987) 337; Comp. Biochem. Physiol. A 128 (2001) 417]. The structures involved include the optic tectum, pretectal nuclei and an area within the mesencephalic tegmentum. Here we investigate the structures and pathways involved in innate stimulus recognition in avian, rodent and primate species. We discuss innate stimulus preferences in maternal imprinting in chicks and argue that these preferences are due to innate visual recognition of conspecifics, entirely mediated by subtelencephalic structures. In rodent species, brainstem structures largely homologous to the components of the anuran subcortical visual system mediate innate visual object recognition. The primary components of the mammalian subcortical visual system are the superior colliculus, nucleus of the optic tract, anterior and posterior pretectal nuclei, nucleus of the posterior commissure, and an area within the mesopontine reticular formation that includes parts of the cuneiform, subcuneiform and pedunculopontine nuclei. We argue that in rodent species the innate sensory recognition systems function throughout ontogeny, acting in parallel with cortical sensory and recognition systems. In primates the structures involved in innate stimulus recognition are essentially the same as those in rodents, but overt innate recognition is only present in very early ontogeny, and after a transition period gives way to learned object recognition mediated by cortical structures. After the transition period, primate subcortical sensory systems still function to provide implicit innate stimulus recognition, and this recognition can still generate orienting, neuroendocrine and emotional responses to biologically relevant stimuli.

 

Separate, Parallel Sensory and Hedonic Pathways in the Mammalian Somatosensory System

Brain Research Bulletin 58: 243-260 (2002)  PDF

Abstract:  We propose that separate sensory and hedonic representations exist in each of the primary structures of the somatosensory system, including brainstem, thalamic and cortical components. In the dorsal horn of the spinal cord, the hedonic representation, which consists primarily of nociceptive-specific, wide dynamic range, and thermoreceptive neurons, is located in laminae I and II, while the sensory representation, composed primarily by low-threshold and wide dynamic range neurons, is found in laminae III through V. A similar arrangement is found in the caudal spinal trigeminal nucleus. Based on the available anatomical and electrophysiological data, we then determine the corresponding hedonic and sensory representations in the area of the dorsal column nuclei, ventrobasal and posterior thalamic complex, and cortex. In rodent primary somatosensory cortex, a hedonic representation can be found in laminae Vb and VI. In carnivore and primate primary and secondary somatosensory cortical areas no hedonic representation exists, and the activities of neurons in both areas represent the sensory aspect exclusively. However, there is a hedonic representation in the posterior part of insular cortex, bordering on retroinsular cortex, that receives projections from two thalamic areas in which hedonics are represented. The functions of the segregated components of the system are discussed, especially in relation to the subjective awareness of pain.

 

Fear and Power-Dominance Drive Motivation: Neural Representations and Pathways Mediating Sensory and Mnemonic Inputs, and Outputs to Premotor Structures

Neuroscience and Biobehavioral Reviews 26: 553-579 (2002)  PDF

Abstract:  Based on the available literature on activation of brain structures by fear- and anger-inducing stimuli, on the effects of electrical and chemical stimulation and lesions of candidate structures, and on connectional data, we propose that both the fear and power-dominance drives are represented in four distinct locations: the medial hypothalamus, lateral/dorsolateral periaqueductal gray, midline thalamic nuclei, and medial prefrontal cortex. The hypothalamic fear representation is located in the dorsomedial and posterior hypothalamic nuclei, the midbrain representation in the caudal part of the lateral/dorsolateral periaqueductal gray, the thalamic representation primarily in parts of the paraventricular and reuniens thalamic nuclei, and the cortical representation in prelimbic cortex. The hypothalamic power-dominance representation is located in the anterior hypothalamic nucleus, dorsomedial aspect of the ventromedial nucleus, and in adjacent parts of the medial preoptic area. The corresponding midbrain representation occurs in rostral part of the lateral/dorsolateral periaqueductal gray, and the thalamic representation in parts of the paraventricular, parataenial, and reuniens thalamic nuclei. We discuss sensory/mnemonic inputs to these representations, and outputs to premotor structures in the medulla, caudate-putamen, and cortex, and their differential contributions to involuntary, learned sequential, and voluntary motor acts. We examine potential contributions of neuronal activities in these representations to the subjective awareness of fear and anger.

 

The Medial Pain System: Neural Representations of the Motivational Aspects of Pain

Brain Research Bulletin 59: 163-180 (2002)  PDF

Abstract:  In this article, we propose that the pathways mediating the motivational aspect of pain originate in laminae VII and VIII of the spinal cord, and in the deep layers of the spinal trigeminal complex, and projections from these areas reach three central structures where pain motivation is represented, the ventrolateral quadrant of the periaqueductal gray, posterior hypothalamic nucleus, and intralaminar thalamic nuclei. A final representation of the motivational aspect of pain is located within the anterior cingulate cortex, and this representation receives inputs from the intralaminar nuclei. Outputs from these representations reach premotor structures located in the medulla, striatum, and cingulate premotor cortex. We discuss pathways and structures that provide inputs to these representations, including those involved in producing involuntary (innate) and instrumental responses which occur in response to the recognition of stimuli associated with footshock and other nociceptive stimuli.

 

On the Neural Correlates of Object Recognition Awareness: Relationship to Computational Activities and Activities Mediating Perceptual Awareness

Consciousness and Cognition 11: 51-77 (2002)  PDF

Abstract:  Based on theoretical considerations of Aurell (1979) and Block (1995), we argue that object recognition awareness is distinct from purely sensory awareness and that the former is mediated by neuronal activities in areas that are separate and distinct from cortical sensory areas. We propose that two of the principal functions of neuronal activities in sensory cortex, which are to provide sensory awareness and to effect the computations that are necessary for object recognition, are dissociated. We provide examples of how this dissociation might be achieved and argue that the components of the neuronal activities which carry the computations do not directly enter the awareness of the subject. The results of these computations are sparse representations (i.e., vector or distributed codes) which are activated by the presentation of particular sensory objects and are essentially engrams for the recognition of objects. These final representations occur in the highest order areas of sensory cortex; in the visual analyzer, the areas include the anterior part of the inferior temporal cortex and the perirhinal cortex. We propose, based on lesion and connectional data, that the two areas in which activities provide recognition awareness are the temporopolar cortex and the medial orbitofrontal cortex. Activities in the temporopolar cortex provide the recognition awareness of objects learned in the remote past (consolidated object recognition), and those in the medial orbitofrontal cortex provide the recognition awareness of objects learned in the recent past. The activation of the sparse representation for a particular sensory object in turn activates neurons in one or both of these regions of cortex, and it is the activities of these neurons that provide the awareness of recognition of the object in question. The neural circuitry involved in the activation of these representations is discussed.

 

On the Correlation Between Synchronized Oscillatory Activities and Consciousness

Consciousness and Cognition 10: 485-495 (2001)  PDF

Abstract:  Recent experiments have shown that the amplitudes of cortical gamma band oscillatory activities that occur during anesthesia are often greater than amplitudes of similar activities that occur without anesthesia. This result is apparently at odds with the hypothesis that synchronized oscillatory activities constitute the neural correlate of consciousness. We argue that while synchronization and oscillatory patterning are necessary conditions for consciousness, they are not sufficient. Based on the results of a binocular rivalry study of Fries et al. (1997), we propose that the degrees of oscillatory strength and synchronization of neuronal activities determine the degree of awareness those activities produce. On the other hand, the overal firing rates of neurons in cortical sensory areas are not correlated with the degree of awareness the activities of those neurons produce. The results of the experiment of Fries et al. (1997) appear to conflict with the results of another binocular rivalry experiment, in which monkeys were trained to pull a lever in order to report which stimulus object was being perceived (Leopold & Logothetis, 1996). In the latter experiment, it was demonstrated that the firing rates of neurons in striate cortex did not change during perceptual alterations, while 90% of neurons in inferior and superior temporal cortices changed their firing rate when the perceived image changed. This result led to the conclusion that activities in temporal cortex are correlated with visual awareness, but those in striate cortex are not. We argue that activities in temporal cortex contribute little, if anything, to perceptual awareness, and that their primary function is computational. Thus the correlation between the firing rates of neurons in these areas and the responses of the monkeys is due to the recognition of a particular stimulus object, which in turn is due to the computations made there.

 

Visual Awareness Due to Neuronal Activities in Subcortical Structures: a Proposal

Consciousness and Cognition 9: 86-116 (2000)  PDF

Abstract:  It has been shown that visual awareness in the blind hemifield of hemianopic cats that have undergone unilateral ablations of visual cortex can be restored by sectioning the commissure of the superior colliculus or by destroying a portion of the substantia nigra contralateral to the cortical lesion (the Sprague effect). We propose that the visual awareness that is recovered is due to synchronized oscillatory activities in the superior colliculus ipsilateral to the cortical lesion. These oscillatory activities are normally partially suppressed by the inhibitory, GABAergic contralateral nigrotectal projection, and the destruction of the substantia nigra, or the sectioning of the collicular commissure, disinhibits the collicular neurons, causing an increase in the extent of oscillatory activity and/or synchronization between activities at different sites. This increase in the oscillatory and synchronized character is sufficient for the activities to give rise to visual awareness. We argue that in rodents and lower vertebrates, normal visual awareness is partly due to synchronized oscillatory activities in the optic tectum and partly due to similar activities in visual cortex. It is only in carnivores and primates that visual awareness is wholly due to cortical activities. Based on von Baerian recapitulation theory, we propose that, even in humans, there is a period in early infancy when visual awareness is partially due to activities in the superior colliculus, but that this awareness gradually disappears as the nigrotectal projection matures.

 

The Awareness of Thirst: Proposed Neural Correlates

Consciousness and Cognition 9: 463-487 (2000)  PDF

Abstract:  The neural and endocrine bases of the generation of thirst are reviewed. Based on this review, a hierarchical system of neural structures that regulate water conservation and acquisition is proposed. The system includes primary sensory-receptive areas; secondary sensory structures (circumventricular organs), which detect levels of hormones, including angiotensin II and vasopressin, which are involved in generating thirst; preoptic and hypothalamic structures; and an area within the ventrolateral quadrant of the periaqueductal gray matter. Hodological and other data are used to determine the hierarchical organization of the system. Based on studies of the effects of lesions to various structures within the hierarchy of the system, it is proposed that the awareness of thirst in rodents is either entirely or predominantly due to neuronal activities in a subsection of the ventrolateral periaqueductal gray matter. It is also hypothesized that the awareness of thirst in primates is due to neuronal activities in both the ventrolateral periaqueductal gray and in a region within the medial prefrontal and anterior cingulate cortex.